For mastectomy procedures in Chicago, Illinois, Northwestern Memorial Hospital is highly recommended due to its renowned breast cancer program and experienced surgeons who specialize in both mastectomy and reconstructive surgery, offering advanced, personalized care. University of Chicago Medicine also stands out with its exceptional breast cancer center, providing comprehensive care and state-of-the-art surgical techniques for mastectomy and reconstruction. Additionally, Rush University Medical Center excels in breast cancer surgery, focusing on achieving optimal health outcomes and cosmetic results with a patient-centered approach. These hospitals are among the best in Chicago, providing expert surgical care and robust support throughout the treatment and recovery process.