Sidney & Lois Eskenazi Hospital, part of Eskenazi Health, serves as a cornerstone of public health in Marion County. Established in 1859, it has evolved from a smallpox treatment facility to a comprehensive healthcare system. In December 2013, the hospital relocated to a state-of-the-art campus designed to promote health, wellness, and sustainability. The new facility emphasizes patient-centered care, integrating mental and physical health services.​

• Trauma Care: Home to Indiana's first adult Level I trauma center, providing comprehensive emergency services.​ 

• Burn Services: Operates the state's only verified adult burn center, offering specialized burn care.​ 

• emergency Medicine: The Michael & Susan Smith Emergency Department is equipped to handle various acute conditions.

• Mental Health Services: Integrated mental health care through the Sandra Eskenazi Mental Health Center.​

• Women's and Children's Services: Provides comprehensive care, including a Neonatal Intensive Care Unit (NICU).​

• Patient-Centered Care: Emphasizes comprehensive care that integrates mental and physical health services.​

• Community Outreach: Engages in numerous community programs to promote health and wellness.​

• Sustainability Efforts: Focuses on environmental sustainability through green building practices and local food sourcing.​

• Employee Engagement: Prioritizes a positive workplace culture to enhance patient care and staff satisfaction.

• Mission: To advocate, care, teach, and serve, with special emphasis on the vulnerable populations of Marion County.​ 

• Vision: To enhance continuously our ability to meet the needs of the underserved and all people of Marion County, to be economically sound, and to lead innovatively in clinical care, research, education, and service excellence

• LEED Gold Certification: The hospital is Indiana's first LEED Gold certified health care campus, reflecting its commitment to sustainability.​

• Top 20 Most Beautiful Hospitals: Recognized by Soliant Health for its architectural design and healing environment

• Excellence in Employment Engagement: Awarded by Huron/Studer for outstanding employee engagement and workplace culture

• Best Places to Work: Named among America's Best Mid-Size Employers by Forbes Magazine