In 1952, Dow Medical College (DMC) was attached with JCH. In August 1954 the National Assembly of Pakistan authorized the Basic Medical Sciences Institute (BMSI), as basic sciences education was deemed crucial to establishing a centre for higher medical education. After its initial establishment at DMC, Karachi, the Government of Pakistan changed the site for the development of BMSI to a building situated at the site of JCH. The Indiana University with its staff embarked on the establishment of BMSI, headed by Dr. Paul A. Nicoll, Prof. of Physiology who deserves major credit for accomplishment of this assignment. He was ably assisted by Dr. Osgood D Priddle, Prof. of Pharmacology and Dr. Rolla N. Harger, Prof. of Biochemistry. The BMSI with six departments and laboratories, including Anatomy, Biochemistry, Microbiology, Pathology, Pharmacology and Physiology, was thus established as the most updated medical institution of its time. The official opening ceremony was held on 11th April, 1959. Speakers on this occasion were the President of Pakistan, General Muhammad Ayub Khan, President of Indiana University, Dr. Harman B. Wells and Director General Health, Col. M. Jaffer.

• Accident & Emergency: Provides immediate medical attention for acute illnesses and injuries.

• Medicine: Offers comprehensive care across multiple medical specialties.

• Surgery: Conducts general and specialized surgical procedures.

• Thoracic Medicine: Focuses on respiratory system disorders.

• Radiotherapy/Oncology: Provides cancer treatment services.

• Dermatology: Addresses skin-related conditions.

• Psychiatry: Offers mental health services.

• Nephrology: Specializes in kidney-related diseases.

• Vision: To be a leading healthcare provider and educational institution in Pakistan, recognized for excellence in patient care, medical education, and research.

• Mission: To deliver high-quality, patient-centered healthcare services and postgraduate medical education with a commitment to continuous improvement and innovation. JPMC aims to advance medical knowledge, improve health outcomes, and serve the community with integrity and compassion

JPMC has received numerous awards and recognitions for its outstanding contributions to healthcare and medical education. The hospital is accredited by the Pakistan Medical and Dental Council (PMDC) and the College of Physicians and Surgeons Pakistan (CPSP), reflecting its adherence to high standards of medical care. These accolades underscore JPMC's dedication to providing exceptional healthcare services and its role as a leader in the medical field in Pakistan.