As early as 1810, the "Institute for the Training of Skilled Field Surgeons" was established based on the need to educate and equip doctors with the skills needed militarily, not least after the wars Sweden had been involved in during the era. In 1817, the name was changed to the Royal Carolinian Medical-Surgical Institute, which would later be simplified to Karolinska Institutet, KI.

From the beginning, the institute had a strong connection between research, teaching and healthcare, and its location opposite the Serafimer Hospital on Kungsholmen enabled a symbiosis between theory and practice. During the 19th century, the institute developed into a leading center for medical education and research in Sweden. It was here that Alfred Nobel had a significant interest and later donated money to establish the Nobel Prize in Physiology or Medicine.

• Cardiology: Ranked among the top 20 globally for heart care.

• Neurosurgery: Recognized for excellence in brain and spinal surgeries.

• Neurology: Leading research and treatment in neurological disorders.

• Endocrinology: Specialized care for hormonal and metabolic conditions.

• Pediatrics: Home to the Astrid Lindgren Children's Hospital, offering comprehensive pediatric services.

• Oncology: Advanced cancer treatment and research facilities.

• Transplantation Medicine: Expertise in organ transplants and related care.

• Orthopedics: Specialized in musculoskeletal disorders and surgeries.

• Obstetrics and Gynecology: Comprehensive maternal and reproductive health services.

• Infectious Diseases: Advanced diagnostics and treatment options.

Karolinska University Hospital Solna is committed to providing high-quality, patient-centered care. It has been consistently ranked among the top hospitals globally, including being named the world's 6th best hospital in 2023 by Newsweek. The hospital is known for its innovative approach to healthcare, integrating cutting-edge technology with compassionate care.

Vision: To lead the way in health and healthcare development, including severe diseases where no sufficient treatment exists. 

Mission: To cure and relieve tomorrow what no one can cure and relieve today, by advancing medical research, education, and patient care.

• World’s Best Hospitals 2023: Ranked 6th globally by Newsweek.

• World’s Best Specialized Hospitals 2025: Ranked 5th globally.