Newham University Hospital opened on December 14, 1983, replacing Queen Mary's Hospital for the East End and East Ham Memorial Hospital. It was initially named Newham General Hospital and underwent several expansions, including the addition of a maternity department in 1985 and further development in 1986 with new facilities. The hospital's name was changed to Newham University Hospital in 2004. It provides acute general hospital services and is known for its commitment to serving the local community with a broad range of medical services.

The hospital offers a variety of specialties including emergency care, surgery, women's and children's health, maternity services, and specialist medicine. It also has specialized units such as the renal unit in the Gateway Surgical Centre, a special care baby unit, a rehabilitation department, and an academic center.

Quality assurance at Newham University Hospital involves multiple audits and reviews. Despite facing challenges in some areas, the hospital has shown improvements in others. For example, the emergency department has good processes for ensuring evidence-based care, and the maternity services are within national guidelines. The hospital also actively participates in national audits such as the Heart Failure Audit and the British Thoracic Society Smoking Cessation Audit.

The vision and mission of Newham University Hospital are aligned with the broader goals of Barts Health NHS Trust. They focus on providing safe, high-quality care to the diverse community they serve, fostering a supportive and inclusive environment for patients and staff, and continually improving their services through innovation and adherence to best practices.

Newham University Hospital has received several accolades for its services. The hospital's maternity services are working towards Level 3 of the UNICEF UK Baby Friendly Initiative, promoting good care for newborn babies. Additionally, the hospital has achieved a B grading in the Sentinel Stroke National Programme, reflecting effective practice in stroke care.