Established in February 1947, Shanghai First Maternity and Infant Hospital is one of the earliest maternal and child health centers in China. It became affiliated with Tongji University in 2006. The hospital is recognized for its commitment to providing high-quality maternal and child healthcare services and adheres to national policies to improve medical services, control costs, and benefit the public.

The hospital specializes in obstetrics, gynecology, neonatology, family planning, reproductive immunology, and maternal and child health. It offers services such as breast and cervical screening, surgical anesthesia, traditional Chinese medicine (TCM), and pediatrics.

In 1992, the hospital was part of the first batch of baby-friendly hospitals in China. It was rated as a Grade 3, Class A specialized hospital in 1995. The hospital follows strict quality standards and has received various recognitions for its high standards in patient care.

The hospital's mission is to serve women and children with superb technologies and excellent services, adhering to the principle of public welfare and patient-centered care. The vision is to continuously improve medical services and quality while controlling costs to benefit people.

The hospital has received numerous awards and recognitions, including being named a baby-friendly hospital and a designated healthcare unit for cadres in Shanghai. It is also a Model Unit issued by Shanghai Municipality.