The Government Medical College, Thiruvananthapuram (also known as Thiruvananthapuram Medical College) is in Thiruvananthapuram (the capital of Kerala), India. Founded in 1951, it was dedicated by Prime Minister Jawaharlal Nehru and is Kerala's oldest medical college. The college was known in early records as Medical College (of Thiruvananthapuram), since it was the only medical institute in the state at its inception. Its campus houses several hospitals and institutions in addition to Medical College Hospital (MCH), including the Colleges of Nursing and Pharmaceutical sciences, the Regional Cancer Centre, Thiruvananthapuram Dental College, Sree Chitra Tirunal Institute for Medical Sciences and Technology, the Priyadarshini Institute of Paramedical Sciences and the Sree Avittom Thirunal Hospital for Women and Children (SAT Hospital). The Regional Institute of Ophthalmology (RIO), also a part of the college, is being upgraded to a national-level independent institute. The School of Optometry is also on campus.

SAT Hospital maintains high standards in patient safety, infection control, and clinical care. Its designation as a Centre of Excellence for Rare Diseases and its role as a DNB examination and training center reflect its commitment to quality, research, and academic excellence.